PREVORA for Patients

PREVORA 100mg/ml Dental Solution is a 10% chlorhexidine formulation combined with sealant technology.

PREVORA is licensed for the prevention of tooth decay in high-risk adults. Experience with PREVORA spans clinical studies and real-world use over more than 20 years.1-6

PREVORA provides you with a new management option for your high-risk patients, including those who are difficult to treat. Used as an adjunct to standard practices, PREVORA reduces the bacteria that cause tooth decay and gum disease. Improvement can be seen within days and protection is long-lasting.

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How PREVORA works

PREVORA forms a long-acting antibacterial tooth coating that provides effective and long-lasting protection.

The effects of PREVORA's active ingredient are well-established:

  • Chlorhexidine’s positive charge means it binds strongly to negatively charged oral surfaces, forming a slow-release reservoir within the mouth.
  • Chlorhexidine reduces the harmful bacteria that cause oral dysbiosis, tooth decay and gum disease, allowing healthy commensal bacteria to recolonise.
  • By modulating the oral biofilm, chlorhexidine reduces the build-up of plaque that can lead to the development of caries and gum disease.

PREVORA reduces oral dysbiosis, and helps restore oral health


How PREVORA is applied

01

PREVORA Stage 1 chlorhexidine coating is applied to all tooth surfaces and dried

02

PREVORA Stage 2 sealant coating is applied to all tooth surfaces and dried


PREVORA can be applied by a dental hygienist, therapist or nurse* in about 10 minutes

*Dental nurses must work under the direction of a GDC registrant.


Who is PREVORA for?

All adults over 45 years old:

  • With poor compliance with oral hygiene practices – including those with mobility or dexterity issues.
  • Wishing to avoid poor oral health/dental cavities in later years of life.

All other adults with one or more of the following:

  • A history of caries
  • Non-responsive bleeding sites
  • Oral dryness – all causes, including:
    • Antihypertensive use
    • Antidepressant use
    • Diabetes
    • Sleep apnoea
    • Radiotherapy
  • Peri-implant mucositis and peri-implantitis
  • Planned aesthetic dentistry
  • Low tolerance of invasive dental care
  • Residential care (elderly/social)

Based on an analysis of the above criteria, it is anticipated that a minimum of 20% of practice patients would be candidates for PREVORA.


Over 20% of adult patients eligible


PREVORA's key features

PREVORA, with its unique formulation and clinical profile, offers several key features for managing oral dysbiosis:

Mechanism of action:

PREVORA utilises a clear, protective chlorhexidine coating as its primary active ingredient. Chlorhexidine is a well-established antiseptic agent known for its antibacterial properties, making it highly effective in reducing the bacteria that cause poor oral health.7,8

Extended protection:

PREVORA contains a high concentration of chlorhexidine (10%) and offers long-lasting protection. Chlorhexidine binds strongly bind to the dentition, resulting in a sustained-release mechanism and a longer duration of antibacterial action.9 Furthermore, a higher concentration of chlorhexidine is associated with a longer treatment effect.10

High efficacy in high-risk adults:

PREVORA has been shown to be effective in preventing tooth decay in high-risk adults.1,2 High-risk individuals include those with a history of multiple cavities, gum disease, limited saliva because of multiple medication use, or poor oral hygiene practices.



Professional use designation:

PREVORA has obtained MHRA approval for the treatment of caries with a professional use designation, eliminating the need for a prescription.11 This designation allows dental hygienists and dental therapists to independently administer PREVORA, enhancing its accessibility and ease of use. Dental nurses can also apply PREVORA, under the direction of a GDC registrant.

Simplicity of administration:

PREVORA is simply painted onto the patient’s teeth. Its application requires minimal training, no special equipment, and it can be delivered without aerosols.

Potential for gum disease management:

As well as caries prevention, PREVORA has demonstrated notable potential in managing gum disease.3-6 An ability to address both caries and gum disease simultaneously would provide significant additive clinical benefit, and further enhance patient acceptability and adherence.


The accompanying Summary of Product Characteristics (SmPC) should be consulted before use.

Become a PREVORA provider today


Discover how you can contribute to the future of preventive oral healthcare by becoming a PREVORA provider.


Find out more
  1. Symington, J.M., Perry, R., Kumar, A., Schiff, R. (2014) Efficacy of a 10% chlorhexidine coating to prevent caries in at-risk community-dwelling adults. Acta Odontol Scand, 72(7), 497–501.
  2. Banting, D.W., Papas, A., Clark, D.C., Proskin, H.M., Schultz, M., Perry, R. (2000) The effectiveness of 10% chlorhexidine varnish treatment on dental caries incidence in adults with dry mouth. Gerodontology, 17, 67–76.
  3. Nguyen, Q.V. (2021) Use of high-concentration chlorhexidine (PREVORA®) for reduction in ‘need for surgery’ in patients with periodontitis. Master’s thesis, University of Toronto.
  4. Sveistrup H., Pepe A., DeHaan, I., Tenenbaum H.C., Turgeon, B., Svendrovski, A. Perry, R. (2023) Preventive dental services in the community: a randomized, controlled trial. [Manuscript submitted for publication].
  5. DiNardo, J. (2018) Preventing poor oral health in older patients with multiple chronic conditions. Oh Canada, Summer, 21–25.
  6. DiNardo, J. (2022) PREVORA is a successful therapy for chronic oral inflammation. [Unpublished data on file, CHX Technologies Inc].
  7. Poppolo Deus, F., Ouanounou, A. (2022) Chlorhexidine in dentistry: pharmacology, uses, and adverse effects. Int Dent J, 72(3), 269–277.
  8. Haydari, M., Bardakci, A.G., Koldsland, O.C., Aass, A.M., Sandvik, L., Preus, H.R. (2017) Comparing the effect of 0.06% -, 0.12% and 0.2% chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: a parallel group, double masked randomized clinical trial. BMC Oral Health 17(1):118.
  9. Puig Silla, M., Montiel Company, J.M., Almerich Silla, J.M. (2008) Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature. Med Oral Patol Oral Cir Bucal, 13(4), E257–260.
  10. Mahendra, A., Koul, M., Upadhyay, V., Dwivedi, R. (2014) Comparative evaluation of antimicrobial substantivity of different concentrations of chlorhexidine as a root canal irrigant: An in vitro study. J Oral Biol Craniofac Res. 4(3):181–185.
  11. SUMMARY OF PRODUCT CHARACTERISTICS, 2011, ‘PREVORA 100mg/ml Dental Solution’, Medicines and Healthcare products Regulatory Agency. Available at: https://mhraproducts4853.blob.core.windows.net/docs/3e1ab3f364a621c3fd4531bdce769bd7df2c7dda